British Air Force Typhoon FGR4s have operated alongside French warplanes in a combined operation targeting an underground arms cache in Syria used by the IS group, according to the UK's MoD.
The location, located using reconnaissance, was thought to be containing munitions and bombs, the release indicated, and was positioned in mountains just above the historic site of Palmyra in the heart of Syria.
"Our fighter planes used precision-guided Paveway IV munitions to strike a number of access tunnels leading to the facility... preliminary assessments suggest the strike was effective," the MoD said.
There was no evidence of any harm to civilians in the strike late on Saturday and each participating jet made a safe return, the ministry further stated.
The Typhoon FGR4s were backed up by a Voyager tanker plane.
The Islamic State group - referred to as ISIS - established extremist governance over parts of both Syria and Iraq before its territorial defeat in 2019.
"This operation demonstrates our UK leadership, and resolve to work closely with our allies, to eliminate any revival of the terrorist group and their dangerous and violent ideologies in the region," the British Defence Secretary the minister remarked.
RAF aircraft have performed surveillance missions over Syrian airspace to "forestall any attempted comeback" of the group after its military defeat at the battle of Baghuz in the year 2019, the MoD reported.
"I must thank every member of our armed forces who took part in this mission for their expertise and their courage," Healey said. "Including them were thousands of British troops stationed over Christmas and New Year. This action, to remove militants who endanger our security, shows how our armed forces are ready to step up, throughout the year, keeping Britain secure at home and strong abroad."
In December, the United States armed forces carried out what it termed a "major assault" on Islamic State objectives in the country, following an attack resulted in the deaths of two US troops and a civilian linguist in Palmyra.
The United Nations says Islamic State still has between 5,000 and 7,000 militants in Syria and Iraq.
